The November – December 2020 Issue of Nutraceuticals Now is now available.
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Some quotes from key personnel, on behalf of the participating companies, an overview and link to the full study below.
“We thank the researchers at the University of Westminster and Coventry University, for this ground breaking study. Being published in a high impact factor journal (Antioxidants) demonstrates the quality of the study design” said Eric Meppem, Commercial Director at Pharmako Biotechnologies.
Mr. Venkatesh, Managing Director at Gencor Pacific, stated “BDNF is necessary for cognitive function associated with learning and memory, therefore this study demonstrates the benefits of Hydrocurc in the Cognitive Health segment”.
Results show that co-supplementation of 500 mg HYDROCURC with 18 mg elemental iron increase levels of BDNF, which is a key necessity for normal neuronal development and cognitive function associated with learning and memory formation. It also exerts a neuroprotective effect and is a big contributor to energy homeostasis. So increased levels of BDNF could enhance cognitive capacity and reduce fatigue.
• Iron is a key factor in maintenance of normal neuronal function and typically dietary iron intakes rage from 12-18 mg a day. Optimal iron levels are essential for BDNF homeostasis.
• Low levels of Ferritin, the serum biomarker of iron, results in low levels of BDNF. Too high levels of Ferritin also impair BDNF levels. So one needs optimal iron levels, as explained above.
However, as the study states:
“Iron intake often does not meet the body’s requirements due to inadequate nutrient intake and poor bioavailability on account of the complexities of iron absorption (such as the influence of dietary iron inhibitors and enhancers), thus leading to widespread iron deficiency. This is a worldwide public health issue as iron deficiency has been attributed to more than 60% of anaemia cases, a condition estimated to affect around two billion people globally”.
The study had 5-groups:
1. Curcumin placebo + 18 mg iron, which is the normal human daily dietary intake
2. 18 mg iron + 500 mg HYDROCURC
3. Curcumin placebo + Higher dose [ pharma dose ] of 65 mg iron
4. Higher dose 65 mg iron + 500 mg HYDROCURC
5. Curcumin placebo + Iron placebo
• The 18 mg Iron + 500 mg HYDROCURC group had a statistically significant increase in BDNF levels between base line and endpoint compared to the 18 mg iron group alone, with a 34.94% increase in BDNF concentration.
• The 18 mg Iron + 500 mg HYDROCURC group also had a statistically significant increase in BDNF levels between baseline and endpoint, compared to the placebo group, with a 53.78% increase in BDNF concentration.
• The 65 mg Iron + 500 mg HYDROCURC also had an increase in BDNF compared to the 65 mg iron supplementation alone but the trend was not statistically significant.
” The current study demonstrates for the first time that the co-administration of a bioavailable formulated curcumin supplement with ferrous sulphate containing 18 mg elemental iron for 42 days results in increased serum BDNF levels. The addition of curcumin may therefore provide a novel approach to iron supplementation and possibly enhance the iron-associated cognitive benefits linked to increased serum BDNF levels”.
Key Takeaway Message:
Today Cognition / Nootropics is a huge sector in our industry, particularly as the importance of cognitive health becomes more apparent. Our study with HYDROCURC is a pathbreaker for this segment, as when co-administered with a normal dietary intake of 18 mg iron, it can increase BDNF levels.
Please see link for full study: https://www.mdpi.com/2076-3921/9/8/645