Mitochondria Supplement Ingredient BioPQQ® Proves its Safety and Efficacy Through Years of Research

Mitochondria Supplement Ingredient BioPQQ® Proves its Safety and Efficacy Through Years of Research

Supplement manufacturers jeopardize brand reputation and credibility when using ingredients not backed by scientific research and testing

The safety and efficacy of ingredients is a major concern and selecting the right ingredients for a manufacturer’s supplement is critical in today’s market. More consumers are choosing daily supplements for a healthier lifestyle and opting for a clean label, meaning they want products made with ingredients they recognize or trust.  According to Market Watch, the supplement industry has a predicted CAGR of 8.8 percent by 2024.

Interest in supplements to support brain health has risen dramatically in recent years. The global brain health supplements market is expected to reach $11.6 billion by 2024, up from $2.3 billion in 2015. Encouraging nerve growth and higher levels of healthy mitochondria are important to the brain’s performance and longevity. BioPQQ has been proven to boost mitochondrial biogenesis, ultimately energizing cells that are critical to brain and heart functioning.

BioPQQ is a safe, all-natural supplement compound manufactured through a proprietary fermentation process that has been fully characterized and widely tested in animals and humans to support its efficacy and safety.

“BioPQQ has been well-studied and validated for its high quality and safety with each batch being tested for food-grade standards,” said Shoji Matsukawa, vice president of Mitsubishi Gas Chemical America.  “Today, nearly two dozen manufacturers in North America use BioPQQ in their product formulas because of this. While there are other PQQ imitations being marketed as also being safe, they don’t have the scientific research or evidence to substantiate those claims.”

BioPQQ is manufactured in Japan by Mitsubishi Gas Chemical Co. and is the only one of its kind to:

  • Receive New Dietary Ingredient (NDI) notification from the U.S. Food & Drug Administration (FDA). The FDA has stringent qualifications. To receive an NDI notification, the product must demonstrate it does not present a significant or unreasonable risk of illness or injury. The FDA favorably approves approximately 30 percent of NDI submissions, attesting to BioPQQ’s safety.


  • Be certified by Informed-Choice and Informed-Sport quality assurance programs, which conduct rigorous checks and testing to ensure products are not contaminated with banned substances. Athletes who see the Informed Choice logo on a product can be assured it is not contaminated with substances banned by the World Anti-Doping Agency (WADA).

The same ingredient is known under the brand name MGCPQQ® in Europe and registered on the European Union’s list of Novel Food Ingredients.

For more information about BioPQQ, visit This product is not intended to diagnose, treat, cure or prevent any disease.

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