d’Or is the first whole fruit cranberry ingredient supplier to follow this protocol,” explains Lukawski.
He says the C-PAC reference standard and associated analytic methods are ‘Fit for Purpose’. Fit for Purpose, means that the methods and reference standards have been scientifically validated and represent the most appropriate approach to authenticate and quantify the bioactive PAC of whole fruit cranberry. “C-PAC is your pillar. Without it, there is no accurate standardization. Lack of standardization leads to more fairy dust cranberry products at the retail level. How can you move forward to conduct a cranberry study or even repeat a study, if you don’t know what is in your starting cranberry powder or what reference standard you started with when doing your testing of biomarkers for standardization?”
Krueger adds that, “It’s the efforts that Fruit d’Or has gone to, to characterize its product’s unique characteristics, that enables them to demonstrate this structure/function claim on the pathogenic bacteria. Other cranberry products may have different activities. It’s incumbent on ingredient manufacturers to test their own unique products in order to make similar claims.”
Lukawski agrees. “This is why we’ve done all this hard work in the first place. Now future studies can be done on soluble and insoluble PAC, because we have the C-PAC reference material, and we can authenticate our starting cranberry powder raw material. Only with identification, authentication and standardization can we link to efficacy in outcome studies. This is what furthers separates us from other whole fruit cranberry suppliers.”
Standardized C-PAC reference material makes research more meaningful
Cranberry ingredients and formulated products will vary from lot to lot because they are affected by every phase of the growing and manufacturing process, including drying and milling. That’s why it is so important to use ‘Fit for Purpose’ methods to authenticate and standardize the bioactive components starting material, then link that to its bioefficacy and standardization.
It was CPS that introduced breakthrough analytic business services s such as Polyphenol Fingerprinting analysis for identification and quantification of PAC via MALDI-TOF MS, in addition to creating the C-PAC reference standard. Krueger notes, “The C-PAC reference standard is a more accurate means of quantifying both soluble and insoluble PAC than the procyanidin A2 dimer reference standard that was previously used.”
These images will change the path of future research
“These scanning electron micrograph images separate the rhetoric from results,” says Lukawski. “Fruit d’Or was the first supplier in the natural cranberry powder industry to identify our starting raw material using the C-PAC as a reference standard. No other cranberry supplier of whole fruit cranberry powder has identified any biomarkers and linked these to outcome studies This means past research studies from other whole fruit cranberry suppliers are encouraging but are outdated, questionable and misleading for both consumers and the future of the cranberry industry. We invite researchers and formulators to use this understanding to support additional research using our Cran Naturelle whole fruit cranberry powder. We feel confident that these studies will lead to better understanding of our product’s bioactivity and health outcomes, beyond urinary tract health.”